Cytokines are secreted peptides or small proteins that regulate the growth and differentiation of cells and coordinate the human immune system. Deregulated expression of cytokines has been associated with many human diseases, especially tumors. In cell culture, recombinant cytokines are used to modulate the activity of the immune system or to decipher the development of tumors.
We offer you the murine, recombinantly expressed cytokines GM-CSF and TNF-α. GM-CSF (granulocyte-macrophage colony-stimulating factor) is secreted by immune and endothelial cells and causes the differentiation of bone marrow precursor cells into granulocytes and macrophages. As a T-cell cytokine, GM-CSF also plays a decisive role in the development of autoimmune inflammatory reactions, e.g. in multiple sclerosis. TNF-α (tumor necrosis factor-α) is a multifunctional signaling substance of the immune system. TNF-α is primarily secreted by macrophages and regulates the activity of various immune cells.