RNAse Inhibitor

Our RNase Inhibitor specifically inhibits eukaryotic RNases (e.g. RNase A, B, C) by non-covalent binding with high affinity (4 x 10-14 M) at a ratio of 1:1. The recombinant protein (49.6 kDa) shows no inhibitory effect on the activity of polymerases or reverse transcriptases. Our RNase inhibitor has a significantly improved resistance to oxidation and is ideally suited for cDNA synthesis and in one-step RT-PCR reactions.

Our RNase Inhibitor does not inhibit the following RNases: I, T1, T2, H, U1, U2 and Cl3.
But is compatible with: SP6, T7, T3 RNA polymerases; AMV, M-MLV reverse transcriptases and Taq DNA polymerases.

Ribonucleases (RNases) are nucleases that specifically degrade ribonucleic acid (RNA) molecules. The human body uses RNases to defend itself against invading microorganisms, which is why RNases are found in body fluids such as tears, saliva, mucus and sweat. RNA experiments are therefore often compromised by contamination with RNases. To increase the yield of your cDNA synthesis and make PCR experiments successful, add our RNase inhibitor to your reaction mixture. Our RNase Inhibitor specifically inhibits eukaryotic RNases!