Growth factors (human)
Growth factors are proteins that are secreted as signals by a cell and transmitted to other cells in order to pass on information. Signal transmission functions by binding the growth factor to its specific membrane receptor. The enzymatic receptors transmit the extracellular “stimulus” through intracellular signal transduction. Growth factors and their receptors are mainly overexpressed in tumors (oncogenes), which leads to uncontrolled cell growth. Targeted tumor therapies therefore attempt to suppress tumor growth by specifically inhibiting growth factor receptors (using monoclonal antibodies or tyrosine kinase inhibitors).
We offer you human, recombinantly expressed growth factors: BDNF, EGF, FGF, IGF, PDGF and VEGF.
Article list
| Products | Article number | Quantity | Shop |
|---|---|---|---|
|
BDNF
Brain-Derived Neurotrophic Factor (human, recombinant)
|
BS.WF.28.0002
|
2 µg
| |
|
BS.WF.28.0010
|
10 µg
| ||
|
BS.WF.28.1000
|
1000 µg
| ||
|
EGF
Epidermal Growth Factor (human, recombinant)
|
BS.WF.1.0100
|
100 µg
| |
|
BS.WF.1.0500
|
500 µg
| ||
|
BS.WF.1.1000
|
1000 µg
| ||
|
FGF acidic
Fibroblast Growth Factor (human, recombinant)
|
BS.WF.2.0010
|
10 µg
| |
|
BS.WF.2.0050
|
50 µg
| ||
|
FGF-2
Fibroblast Growth Factor 2 (human, recombinant)
|
BS.WF.3.0010
|
10 µg
| |
|
BS.WF.3.0050
|
50 µg
| ||
|
BS.WF.3.1000
|
1000 µg
| ||
|
IGF-1
Insulin-like Growth Factor 1 (human, recombinant)
|
BS.WF.5.0020
|
20 µg
| |
|
BS.WF.5.0100
|
100 µg
| ||
|
IGF-2
Insulin-like Growth Factor 2 (human, recombinant)
|
BS.WF.6.0010
|
10 µg
| |
|
BS.WF.6.0050
|
50 µg
| ||
|
PDGF-AA
Platelet-Derived Growth Factor AA (human, recombinant)
|
BS.WF.94.0010
|
10 µg
| |
|
BS.WF.94.1000
|
1000 µg
| ||
|
PDGF-AB
Platelet-Derived Growth Factor AB (human, recombinant)
|
BS.WF.16.0010
|
10 µg
| |
|
PDGF-BB
Platelet-Derived Growth Factor BB (human, recombinant)
|
BS.WF.15.0002
|
2 µg
| |
|
BS.WF.15.0010
|
10 µg
| ||
|
VEGF
Vascular Endothelial Growth Factor (human, recombinant)
|
BS.WF.27.0002
|
2 µg
| |
|
BS.WF.27.0010
|
10 µg
| ||
|
VEGF (121 a.a.)
Vascular Endothelial Growth Factor 121 (human, recombinant)
|
BS.WF.24.0010
|
10 µg
| |
|
VEGF-C
Vascular Endothelial Growth Factor C (human, recombinant)
|
BS.WF.25.0010
|
10 µg
| |
|
VEGF, CHO
Vascular Endothelial Growth Factor CHO (human, recombinant)
|
BS.WF.26.0002
|
2 µg
|
Good to know
BDNF (Brain-Derived Neurotrophic Factor)
BDNF acts on neurons in the peripheral nervous system and central nervous system. It protects existing neurons and synapses and stimulates the growth of new nerve cells, neuronal pathways and synapses.
EGF (Epidermal Growth Factor)
EGF stimulates cell proliferation and differentiation by binding the receptor EGFR (Epidermal Growth Factor Receptor). EGFR plays a key role in the development of epithelial malignancies. It promotes the growth, invasion and metastasis of tumors.
FGF (Fibroblast Growth Factor)
FGFs stimulate cell proliferation, migration and differentiation of endothelial cells, muscle cells and fibroblasts. In addition, angiogenesis is significantly controlled and influenced by FGFs.
IGF (insulin-like growth factor)
IGFs are insulin-like signaling molecules. IGF-1 is primarily secreted by liver cells in order to synthesize and secrete IGF-1. This stimulates hypertrophy (increase in cell size) and hyperplasia (increase in cell number) of most tissues. IGF-2 has a strong mitogenic, anti-apoptotic and growth-stimulating effect.
PDGF (Platelet-Derived Growth Factor)
PDGF has important functions in embryogenesis (especially in kidney, blood vessel, lung and CNS development), cell proliferation and migration, wound healing and angiogenesis. PDGFs have been associated with various diseases such as arteriosclerosis, fibrosis and some tumors.
VEGF (Vascular Endothelial Growth Factor)
VEGF is an important signaling molecule for the formation of blood and lymph vessels as well as for angiogenesis and lymphangiogenesis. Overexpression of VEGF has been associated with the development of some tumors. In tumors, VEGF serves to increase the permeability of blood vessels and thus to open the blood-tumor barrier (facilitated metastasis).